- NICE - Metastatic malignant disease of unknown primary origin in adults: diagnosis and management. Clinical guideline [CG104] Published date: 26 July 2010
- This guideline covers diagnosing and managing secondary cancers in people aged 18 and over when the site of the primary cancer is unknown. This includes people who have had treatment for cancer before. It aims to improve quality of life by offering advice on tests for identifying the site of the primary cancer and options for managing the person’s condition when this cannot be found.
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Published in 2015 – Ann Oncol (2015) 26 (suppl 5): v133-v138. Authors: K. Fizazi, F. A. Greco, N. Pavlidis, G. Daugaard, K. Oien, and G. Pentheroudakis
- Cancers of unknown primary site (CUPs) are metastatic tumours for which a standardised diagnostic work-up fails to identify the site of origin at the time of diagnosis. The updated ESMO Clinical Practice Guidelines provide new information on the definition, incidence and biology, staging and treatment of these cancers, as well as a review of current personalised medicine strategies to identify a minority of CUP patients who can expect to benefit from directed therapy.
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